Fig. 1.

Apolipoprotein A-I mimetic peptide 4F (4F) protects against myocardial infarction (MI)-induced autonomic and myocardium dysfunction. All studies were performed at 24 h after the sham procedure or MI induction: mean arterial pressure (note that this decreased only in the MI+radiocontrast (RC) group; A); heart rate (B); baroreflex sensitivity, as estimated by determining bradycardic response and tachycardic response at low doses of phenylephrine and sodium nitroprusside; note that treatment with 4F completely restored baroreflex sensitivity (C); cardiac output, measured by echocardiography (D); left ventricular ejection fraction, measured by echocardiography (E); and invasive evaluation of left ventricular function, in which a catheter was inserted into the right carotid artery and advanced into the left ventricle to measure left ventricular end-diastolic pressure (F); (n = 8/group, ANOVA).