Synthetic apolipoprotein A-I mimetic peptide 4F (4F) decreases serum levels of troponin I after myocardial infarction (MI) and after radiocontrast (RC) administration. Levels of troponin I were measured in all groups: Sham (sham-operated rats); MI (rats induced to MI by ligation of the left coronary artery); MI+RC (rats induced to MI and receiving, 6 h later, femoral vein injection of iopamidol); MI+4F (rats induced to MI and receiving, 6 h later, intraperitoneal injection of 4F); and MI+RC+4F (rats induced to MI and receiving, 6 h later, femoral vein injection of iopamidol and intraperitoneal injection of 4F). All studies were performed 24 h after sham procedure or MI induction (n = 8/group, ANOVA).