Table 1.
Group |
|||||
---|---|---|---|---|---|
Parameter | Sham | MI | MI+RC | MI+4F | MI+RC+4F |
Creatinine, mg/dL | 0.27 ± 0.02 | 0.57 ± 0.04a,b,c | 0.65 ± 0.04a,b,c | 0.38 ± 0.02d | 0.39 ± 0.02e |
Lactate, mmol/L | 1.54 ± 0.12 | 2.4 ± 0.11f,g,h | 2.66 ± 0.2e,i,j | 1.74 ± 0.2 | 1.87 ± 0.2 |
Triglycerides, mg/dL | 39.8 ± 8.5 | 114.1 ± 14.6d,k,l | 120.0 ± 13.6d,k,h | 43.9 ± 11.6 | 62.58 ± 13.6 |
Cholesterol, mg/dL | 95.7 ± 7.5 | 145.0 ± 10.5f,g,h | 154.8 ± 9.42e,i,h | 93.8 ± 11.4 | 100.9 ± 14.0 |
VLDL, mg/dL | 7.1 ± 0.8 | 23.7 ± 0.95a,b,c | 25.3 ± 1.2a,b,c | 8.62 ± 2.1 | 11.1 ± 2.8 |
LDL, mg/dL | 35.5 ± 4.2 | 118.5 ± 4.8a,b,c | 120.9 ± 5.4a,b,c | 42.7 ± 7.3f | 62.2 ± 5.2f |
HDL, mg/dL | 44.0 ± 4.3 | 57.5 ± 10.7 | 42.3 ± 9.9i,h | 77.8 ± 3.9e | 72.6 ± 4.1e |
Data represent means ± SE. MI, myocardial infarction; RC, radiocontrast; 4F, apolipoprotein A-I mimetic peptide 4F; HDL, LDL, and VLDL, high-, low, and very low-density lipoprotein.
P < 0.0001 vs. Sham,
P < 0.0001 vs. MI+4F,
P < 0.0001 vs. MI+RC+4F,
P < 0.001 vs. Sham,
P < 0.01 vs. Sham,
P < 0.05 vs. Sham,
P < 0.05 vs. MI+4F,
P < 0.05 vs. MI+RC+4F,
P < 0.01 vs. MI+4F,
P < 0.01 vs. MI+RC+4F,
P < 0.001 vs. MI+4F,
P < 0.001 vs. MI+RC+4F.