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. 2020 Jan 22;318(3):R634–R648. doi: 10.1152/ajpregu.00317.2019

Fig. 2.

Fig. 2.

Blockade of the arcuate nucleus with the insulin receptor antagonist S961 decreases lumbar sympathetic nerve activity (LSNA), heart rate (HR), and mean arterial pressure (MAP) in obesity-prone (OP, n = 5), but not obesity-resistant (OR, n = 5) and control (CON, n = 5), rats. Top: representative LSNA traces. Bottom: grouped data showing time course of changes (left) and maximal changes (right) in LSNA (at 67.5 ± 4.0 min), HR (at 72.7 ± 1.3 min), and MAP (at 66.3 ± 5.1 min). Two-way repeated-measures ANOVA revealed significant group (P = 0.005), time (P < 0.0001), and interaction (P < 0.0001) for LSNA; significant group (P < 0.005) and interaction (P < 0.0001), but not time, for HR; and significant group (P < 0.05), time (P < 0.01), and interaction (P = 0.0002) for MAP. *P < 0.05 vs. baseline (0); †P < 0.05 vs. OR and CON.