Fig. 1.

Representative data from each experimental group. A: CX717 alone. B: CX717 followed by a single 5-min episode of hypoxia. C: vehicle injection 2-hydroxypropyl-β-cyclodextrin (HPCD) followed by a single 5-min episode of hypoxia. For each group, compressed records of instantaneous phrenic inspiratory burst frequency (top), arterial blood pressure (middle), and the phrenic neurogram (bottom) are shown at baseline, for 90 min following respective treatments, and during a single 5-min episode of hypoxia and maximum chemoreceptor activation (max challenge) at the end of each experiment (indicated by arrows).