Fig. 11.

Bacteroides relative abundance was associated with the severity of liver disease. Relative counts of Bacteroides in cecum and colon increased with the grade of hepatic steatosis, necrosis and inflammation (A) and were higher in nonalcoholic steatohepatitis (NASH) compared with pigs without steatosis. No differences were observed in distal ileum (DI) across groups or severity of liver injury (B). The percentage of Bacteroides was positively correlated (Pearson) with hepatic composite lesion score in cecum and colon (C), and the percentage of chenodeoxycholic (CDCA) and deoxycholic acids (DCA) in colon (D). *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. n.s., Nonsignificant. DI, distal ileum.