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. 2020 Jan 21;318(3):G531–G541. doi: 10.1152/ajpgi.00346.2019

Fig. 5.

Fig. 5.

Isoproterenol challenge in vivo after 3 wk of diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet in caveolin-3 (Cav-3) overexpression (OE) and transgene negative (TGneg) mice. A: the changes of heart rate (HR) and systolic function under isoflurane anesthesia after intraperitoneal injection of 0.01 mg/kg isoproterenol (n = 9–10 per group). The increase of ejection fraction (EF) fractional shortening (FS) after isoproterenol injection were significantly less in both DDC-fed Cav-3 OE and DDC-fed TGneg mice compared with chow-fed mice. B: the changes of HR and corrected QT (QTc) in awake state after intraperitoneal injection of 0.01 mg/kg isoproterenol (n = 7–9 per group). QTc interval of DDC-fed TGneg mice was significantly higher than that of DDC-fed Cav-3 OE mice at 1, 2, 5 and 10 min after isoproterenol injection. Values are means ± SE. *P < 0.05, **P < 0.01, compared with chow-fed TGneg mice. †P < 0.05, ††P < 0.01, compared with chow-fed Cav-3 OE mice. #P < 0.05, compared with DDC-fed TGneg mice.