Fig. 6.

TRPV4 channel inhibition attenuates H₂O₂-induced Ca²⁺ entry and preserves adrenergic vasoconstriction. A and C: changes in vessel wall [Ca²⁺]_i of intact SEAs exposed to H₂O₂ from male (A) and female (C) mice fed the control diet (CD) or Western-style diet (WD) in the presence of HC-067047 (HC, 1 μM). There were no differences in baseline [Ca²⁺]_i between groups. B and D: vasoconstriction to NE (170 nM) was preserved following H₂O₂ exposure with HC present for intact vessels from males (B) and females (D) irrespective of diet. Values are means ± SE; n = 4–5 vessels per group. *P < 0.05, female vs. male.