Fig. 3.

A: increased expression of IL-1β in colons of olfactory receptor-78 (Olfr-78) knockout (KO) mice treated with dextran sodium sulfate (DSS). Wild-type (WT) and Olfr-78 KO male mice were administered 3% DSS in water for 7 days and RNA from distal colon was isolated for the analysis of proinflammatory cytokine IL-1β expression by real-time RT-PCR (n = 5 for WT and 7 for Olfr-78 KO; *P < 0.05). B: increased myeloperoxidase (MPO) activity in Olfr-78 KO mice treated with DSS compared with WT mice treated with DSS.