Fig. 7.

High-mobility group box-1 protein (HMGB-1) significantly increases cytokine signaling in C57BL/6 mouse lung. Cytokine [IL-1β, IL-10, IL-6, IL-27, IL-17α, IFN-β, and granulocyte-macrophage colony stimulating factor (GM-CSF)] profiles of WT C57BL/6 mice, WT C57BL/6 mice intraperitoneally injected with HMGB-1 (10 μg in a 50-μL injection volume), and Scnn1b mice are shown in log scale (A–G). Male and female cohorts of mice were studied; n = 3 independent observations with replicate measures of cytokines. *P < 0.05.