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High-mobility group box-1 protein (HMGB-1) increases fibrosis in C57BL/6 mouse lung. A–D: Masson’s trichrome labeling in lung from age-matched wild-type (WT) control (CTR) mouse, lung from Scnn1β mouse, lung from WT mouse intraperitoneally injected with HMGB-1, and lung from WT mouse intraperitoneally injected with HMGB-1 and intratracheally instilled with FPS-ZM1. Male and female cohorts of mice were studied. Data represent results of 3 independent studies.
