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Muscone suppresses RANKL-induced signaling pathways in osteoclastogenesis. (A, B) Immunofluorescence staining shows that muscone inhibits RANKL-induced P65 nuclear translocation. (C, D) Muscone suppresses phosphorylation of factors in the NF-kB pathway, including P65, P50, and IkB protein. And muscone also blocks phosphorylation of factors in the MAPK pathways in osteoclastogenesis, including ERK, JNK, and P38. *P < 0.05 vs. the control group, #P < 0.05 vs. the RANKL-induced group.
