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Muscone suppresses the RANKL-induced RANK associated down-stream gene expression. By RT-PCR (A) and western blot (B), muscone firstly suppresses the TRAF6 and the over-expressed NFATc1. And then, muscone withdraws expression levels of MMP-9, Cathepsin K, TRAP, and CTR in RAW264.7 cells. *P < 0.05 vs. the control group, #P < 0.05 vs. the RANKL-induced group.
