Table 1. . Substitution pattern of thiaheterocyclic benzohydroxamic acids 1–3.
| Compound | R1 | R2 | R3 | x | n | Config.† |
|---|---|---|---|---|---|---|
| 1a | H | H | – | 0 | 1 | Para |
| 1b | H | OMe | – | 0 | 1 | Para |
| 1c | F | H | – | 0 | 1 | Para |
| 1d | F | OMe | – | 0 | 1 | Para |
| 1e | H | H | – | 2 | 1 | Para |
| 1f | H | OMe | – | 2 | 1 | Para |
| 1g | F | H | – | 2 | 1 | Para |
| 1h | F | OMe | – | 2 | 1 | Para |
| 1i | Br | H | – | 2 | 1 | Para |
| 1j | H | H | – | 1 | 1 | Para |
| 1k | F | H | – | 1 | 1 | Para |
| 1l | H | H | – | 2 | 0 | Para |
| 1m | F | H | – | 2 | 0 | Para |
| 1n | H | H | – | 0 | 1 | Meta |
| 1o | F | H | – | 0 | 1 | Meta |
| 1p | H | H | – | 2 | 1 | Meta |
| 1q | F | H | – | 2 | 1 | Meta |
| 1r | Ph | H | – | 2 | 1 | Meta |
| 1s | H | H | – | 2 | 0 | Meta |
| 1t | F | H | – | 2 | 0 | Meta |
| 1u | Br | H | – | 1 | 0 | Meta |
| 2a | H | H | H | – | – | – |
| 2b | H | Bn | H | – | – | – |
| 2c | 5-Br | H | H | – | – | – |
| 2d | 5-Br | Bn | H | – | – | – |
| 2e | 5-Ph | H | H | – | – | – |
| 2f | 5-Ph | Bn | H | – | – | – |
| 2g | 6-Br | H | H | – | – | – |
| 2h | 6-Br | Bn | H | – | – | – |
| 2i | 6-Ph | H | H | – | – | – |
| 2j | 6-Ph | Bn | H | – | – | – |
| 2k | H | H | Me | – | – | – |
| 3a | H | – | – | 0 | 1 | Cis |
| 3b | Cl | – | – | 0 | 1 | Cis |
| 3c | CF3 | – | – | 0 | 1 | Cis |
| 3d | H | – | – | 2 | 1 | Cis |
| 3e | Cl | – | – | 2 | 1 | Cis |
| 3f | CF3 | – | – | 2 | 1 | Cis |
| 3g | H | – | – | 1 | 1 | Cis |
| 3h | H | – | – | 0 | 2 | Cis |
| 3i | Cl | – | – | 0 | 1 | Trans |
| 3j | H | – | – | 0 | 2 | Trans |
†The para- and meta-configuration for compound 1 refers to the position of the hydroxamic acid group on the aromatic ring with respect to the aminomethyl substituent.