Figure 3. . Mean gametocytemia clearance during chloroquine/primaquine regimen according to SLCO1B1 haplotypes.

Generalized estimating equations method with age, gender, co-medication, gametocytemia baseline level, CYP2C8 genotypes and genetic ancestry as covariates; gene*time p_FDR = 0.024 and d = 1.20. A lower gametocytemia clearance rate over time by SLCO1B1*14 carriers compared with SLCO1B1*1a and SLCO1*1b allele carriers is represented (on second day: *1a vs *14; p = 0.001 and *1b vs *14; p = 0.002). Gametocytemia means are presented as gametocytes/ul (for details, see ‘Patients & methods’ section).