Table 2. . Mean parasitemia over treatment time according to ABCB1 and SLCO2B1 genes.

Gene	Treatment	Mean parasitemia (parasites/μl)			p		pFDR		d†
					Gene	Gene*time	Gene	Gene*time
ABCB‡		CGC/CGC (n = 43)	TnonGT (n = 83)	Others (n = 31)
	Day 0	3894.85	3574.30	3680.04
		(3211.5–4723.6)	(2728.8–4681.8)	(2729–4962.5)
	Day 1	360.53	244.93	279.32	0.568	0.044	NS	0.132	0.41
		(186.23–697.95)	(141.20–424.86)	(153.34–508.80)
	Day 2	0.44	0.78	1.98
		(0.12–1.67)	(0.29–2.10)	(0.55–7.12)
	Day 3	0.01	0.02	0.01
		(0.005–0.014)	(0.012–0.048)	(0.004–0.025)
SLCO2B1§		AA (n = 26)	AG (n = 79)	GG (n = 50)
	Day 0	3626.79	3722.19	3758.23
		(2734.5–4810.2)	(2879.6–4811.3)	(2809.1–5028.0)
	Day 1	321.52	339.01	201.12	0.073	<0.0002	NS	0.002	0.89
		(163.85–630.90)	(225.43–509.82)	(82.73–488.94)
	Day 2	0.10	0.86	3.23
		(0.02–0.48)	(0.33–2.28)	(0.99–10.54)
	Day 3	0.01	0.02	0.01
		(0.004–0.018)	(0.011–0.036)	(0.005–0.030)

Mean parasitemia adjusted for age, gender, genetic ancestry, co-medication and parasitemia baseline level.

Parasitemia is expressed as geometric mean (95% CI).

^†Effect size Cohen's d.

^‡Haplotypes based on SNPs 3435C>T, 2677G>A/T and 1236C>T.

^§Genotypes from SNP 935G>A.

NS: Not significant.