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. 2020 Mar 20;11:126. doi: 10.3389/fendo.2020.00126

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Copyright © 2020 Fernández, Díaz, Bongiovanni, Gallucci, Bértola, Gardeñez, Lioi, Bertolin, Galliano, Bay, Bottasso and D'Attilio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of glucose doses (5 mM, A; 10 mM, B; 20 mM, C; 40 mM, D) on cortisol-induced inhibition of Mtbi-blastogenesis by peripheral blood mononuclear cells (PBMC) from controls (Co), patients with type 2 diabetes (DM), with pulmonary tuberculosis (TB) or with TB and DM (TB-DM). Mtbi: γ-irradiated H37Rv M. tuberculosis strain. Results are shown as Stimulation index (SI: average of counts per minute -cpm- in Mtbi stimulated cultures/average of cpm in unstimulated cultures). Box plots show median values, 25–75 percentiles from data in each group with maximum and minimum values. ⁺different from Co, p < 0.04; ^&different from TB, p < 0.02; ^#different from DM, in each case when comparing the same treatment between groups, p < 0.05; *different from cultures without cortisol and from those treated with 0.1 uM cortisol within the same group, p < 0.05.