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. 2020 Mar 20;11:126. doi: 10.3389/fendo.2020.00126

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Copyright © 2020 Fernández, Díaz, Bongiovanni, Gallucci, Bértola, Gardeñez, Lioi, Bertolin, Galliano, Bay, Bottasso and D'Attilio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IFN-γ production by cultures of peripheral blood mononuclear cells (PBMC) from controls (Co), patients with type 2 diabetes (DM), with pulmonary tuberculosis (TB) or with TB and DM (TB-DM), stimulated with Mtbi and treated with glucose 5 mM (A) and 20 mM (B) with or without cortisol (1 μM). Mtbi: γ-irradiated H37Rv M. tuberculosis strain. Box plots show median values, 25–75 percentiles from data in each group with maximum and minimum values. ⁺different from Co, p < 0.04; ^#different from DM, p < 0.05; in each case when performing between-group comparisons for the same treatment; *different from cultures without cortisol within the same group p < 0.03.