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. 2020 Mar 20;7:95. doi: 10.3389/fmed.2020.00095

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Copyright © 2020 Kawamura, Imamura, Kobayashi, Taniguchi, Nakazawa, Kato, Namba-Hamano, Abe, Uemura, Kobayashi and Nonomura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oral administration of nano-Si particles alleviates interstitial macrophage infiltration and tubular apoptosis. Representative images of (A) CD68 staining and (B) terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) of the renal tissues at 72 h after surgery in the sham, IRI, IRI + nano-Si, and IRI + large-Si groups. (C) Quantitative analysis of the images showing changes in the ratio of CD68-positive areas to the total area of the section. (D) Quantitative analysis of the images showing changes in the ratio of TUNEL-positive cells to the total number of cells. Bars represent means ± standard error of the mean. *p < 0.05, **p < 0.01, n = 6.