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. 2020 Mar 20;11:338. doi: 10.3389/fphar.2020.00338

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Copyright © 2020 Li, Wu, Chen, Wang, Guo, Zhao, Zhao, Wang, Liu and Yan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The concentrations of NE and 5-HT were significantly decreased in the model group compared to the control group (p < 0.01). When the CUMS mice were treated with Flu and IRFV, their levels of 5-HT observably increased (p < 0.01, p < 0.05). NA levels significantly increased only in the IRFV-H group (p < 0.05). In contrast, CRF increased significantly in the model group compared to the control group (p < 0.01). After treatment with Flu and IRFV, the levels of CRF significantly increased compared to the model group (p < 0.01, p < 0.05), but no obvious difference was observed in the IRFV-L group (p > 0.05). ^##p < 0.01 vs the control group; *p < 0.05, **p < 0.01 vs the model group.