Table 1.
Clinical and laboratory data of patients with CKD stratified by eGFR
| Variable | All patients | eGFR | P | ||||
|---|---|---|---|---|---|---|---|
| >90 | 90‐60 | 60‐30 | 30‐15 | <15 | |||
| n | 160 | 10 | 51 | 38 | 32 | 26 | |
| Age (years) | 75.29 ± 12.08 | 55 ± 4.690* | 74.13 ± 11.86 | 76.87 ± 11.08 | 80.52 ± 7.779 | 73.23 ± 13.00 | <.0001 |
| Sex, M/F | 99/61 | 7/3 | 32/19 | 20/18 | 16/16 | 20/6 | |
| BMI, kg/m2 | 21.8 ± 4.0 | 22.4 ± 5.3 | 21.7 ± 4.5 | 21.4 ± 3.7 | 20.8 ± 4.8 | 20.4 ± 3.2 | .32 |
| NGAL (ng/mL) | 402.9 ± 285.2 | 157.6 ± 64.04 | 228.3 ± 127.3 | 346.9 ± 159.4 | 552.9 ± 323.5 | 729.5 ± 282.7 | <.0001 |
| CysC (mg/L) | 3.038 ± 2.489 | 0.9230 ± 0.2486 | 1.367 ± 0.4260 | 2.776 ± 1.610 | 4.445 ± 1.971 | 5.771 ± 3.455 | <.0001 |
| eGFR (mL/mim/1.73 m2) | 47.5 ± 28.06 | 94.54 ± 3.036 | 75.31 ± 8.281 | 44.06 ± 8.620 | 23.51 ± 3.905 | 10.60 ± 2.463 | <.0001 |
| Urea (mmol/L) | 14.24 ± 9.377 | 5.724 ± 1.554 | 6.755 ± 2.557 | 12.67 ± 5.724 | 19.67 ± 6.197 | 26.82 ± 8.776 | <.0001 |
| Cr (μmol/L) | 207 ± 195.7 | 65.00 ± 14.77 | 75.72 ± 19.62 | 132.8 ± 26.48 | 237.6 ± 51.46 | 585.7 ± 186.3 | <.0001 |
| UA (μmol/L) | 350.6 ± 119.4 | 333.3 ± 53.62 | 318.8 ± 86.28 | 355.4 ± 147.7 | 345.4 ± 98.26 | 409.8 ± 150.7 | .0906 |
| Ca (mmol/L) | 2.16 ± 0.1747 | 2.319 ± 0.1331 | 2.191 ± 0.1538 | 2.200 ± 0.1520 | 2.155 ± 0.1372 | 2.004 ± 0.2084 | <.0001 |
| Phos (mmol/L) | 1.207 ± 0.3368 | 1.156 ± 0.1884 | 1.057 ± 0.1875 | 1.124 ± 0.2029 | 1.271 ± 0.3394 | 1.543 ± 0.4805 | <.0001 |
| ALT (U/L) | 18.6 ± 14.94 | 24.29 ± 8.365 | 20.59 ± 15.57 | 15.92 ± 5.569 | 15.72 ± 12.72 | 17.70 ± 23.72 | .3917 |
| AST (U/L) | 22.54 ± 17.70 | 22.57 ± 3.666 | 23.40 ± 14.45 | 21.49 ± 5.773 | 25.98 ± 34.03 | 18.27 ± 5.920 | .6396 |
| ALP (U/L) | 98.22 ± 53.85 | 79.48 ± 23.98 | 88.53 ± 45.82 | 94.70 ± 26.31 | 103.5 ± 76.31 | 123.6 ± 66.66 | .0886 |
| GGT (U/L) | 41.06 ± 65.09 | 24.43 ± 17.80 | 31.57 ± 27.24 | 37.01 ± 19.68 | 32.86 ± 26.20 | 53.38 ± 48.41 | .4123 |
| TC (mmol/L) | 4.289 ± 1.153 | 4.809 ± 0.7166 | 4.322 ± 1.261 | 4.250 ± 1.248 | 4.410 ± 0.9596 | 4.085 ± 1.246 | .6019 |
| TG (mmol/L) | 1.592 ± 1.567 | 1.387 ± 0.7574 | 1.833 ± 2.320 | 1.433 ± 0.7608 | 1.616 ± 1.249 | 1.480 ± 1.034 | .8049 |
| HDL‐C (mmol/L) | 0.9985 ± 0.3106 | 1.263 ± 0.4109 | 1.043 ± 0.3243 | 1.030 ± 0.2978 | 0.9489 ± 0.2208 | 0.8235 ± 0.2602 | .0025 |
| LDL‐C (mmol/L) | 2.797 ± 0.8249 | 3.178 ± 0.5335 | 2.716 ± 0.9717 | 2.775 ± 0.8628 | 2.969 ± 0.6507 | 2.750 ± 0.7946 | .4895 |
| LPa (mg/L) | 376 ± 347.6 | 419.1 ± 392.8 | 321.0 ± 364.5 | 409.1 ± 391.6 | 427.4 ± 290.7 | 393.3 ± 328.6 | .7153 |
| TP (g/L) | 62.19 ± 7.541 | 64.96 ± 5.790 | 61.20 ± 9.428 | 64.00 ± 8.401 | 62.24 ± 5.811 | 61.27 ± 4.090 | .4167 |
| ALB (g/L) | 34.3 ± 5.119 | 39.72 ± 4.067 | 35.11 ± 6.225 | 34.36 ± 4.574 | 32.69 ± 3.164 | 32.47 ± 3.872 | .0015 |
| CRP (mg/L) | 4.4 ± 1.5 | 3.4 ± 2.7 | 5.7 ± 1.9 | 4.0 ± 1.3 | 5.4 ± 1.7 | 4.6 ± 1.2 | .56 |
| RBC (1012/L) | 3.567 ± 0.7640 | 4.470 ± 0.4642 | 3.955 ± 0.6736 | 3.774 ± 0.6556 | 3.048 ± 0.5585 | 3.071 ± 0.5866 | <.0001 |
| HGB (g/L) | 108.1 ± 22.43 | 134.0 ± 14.05 | 119.6 ± 21.96 | 113.3 ± 17.00 | 92.59 ± 16.38 | 95.22 ± 15.97 | <.0001 |
| HCT % | 32.65 ± 6.687 | 40.15 ± 4.082 | 36.18 ± 6.122 | 34.24 ± 4.889 | 27.74 ± 5.207 | 28.73 ± 5.061 | <.0001 |
| MCV (fL) | 91.72 ± 5.992 | 90.77 ± 4.073 | 91.47 ± 6.468 | 91.12 ± 6.706 | 91.13 ± 4.601 | 94.01 ± 5.882 | .3929 |
| MCH (pg) | 30.44 ± 2.189 | 30.45 ± 1.787 | 30.20 ± 2.546 | 30.12 ± 2.160 | 30.47 ± 1.469 | 31.21 ± 2.295 | .419 |
| MCHC (g/L) | 331.9 ± 11.41 | 335.7 ± 7.146 | 330.0 ± 12.19 | 330.8 ± 10.77 | 334.6 ± 11.11 | 332.0 ± 12.40 | .4829 |
P‐values are for comparison across all six groups from one‐way analysis of variance.
Abbreviations: ALB, albumin; ALT, alanine aminotransferase; ALP, alkaline phosphatase; AST, aspertate transferase; BMI, body mass index; Ca, calcium; Cr, creatinine; CRP, C‐reactive protein; CysC, cystatin C; eGFR, evaluated glomerular filtration rate; GGT, gamma‐glutamyl transferase; HCT, hematocrit; HDL‐C, high‐density lipoprotein cholesterol; HGB, hemoglobin; LDL‐C, low density lipoproteincholesterol; LPa, lipoprotein a; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin contentration; MCV, mean corpuscular volume; NGAL, neutrophil gelatinase‐associated lipocalin; Phos, phosphorus; RBC, red blood cell; TC, total cholesterol; TG, Total triglyceride; TP, total protein; UA, uric acid .