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. 2020 Mar 27;18:75. doi: 10.1186/s12916-020-01530-z

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© The Author(s) 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Quality assessment using Risk of Bias 2 tool. a Quality assessment of 32 different studies demonstrating low, high or some concerns of risk of bias. Five individual domains assessed as well as overall judgement. b Summary of the risk of bias assessments for all papers across 5 domains. ITT, intention to treat; PP, per protocol