TABLE 2.
Estimated plasma folate concentrations corresponding to the red blood cell folate concentration of 906 nmol/L using data from the intervention group, stratified by subgroups1
| Median plasma folate concentration in nmol/L (95% CI) |
Median difference (95% CI) |
|
|---|---|---|
| Overall | 25.5 (24.6, 26.4) | — |
| Time | ||
| Baseline | 25.7 (23.0, 29.7) | Reference |
| Month 6 | 25.2 (23.9, 26.5) | −0.5 (−4.7, 2.6) |
| Folic acid dosage | ||
| 100 μg/d | 38.4 (33.3, 45.8) | 13.9 (8.7, 21.5) |
| 400 μg/d | 24.4 (23.1, 25.9) | Reference |
| 4000 μg/d | 22.0 (20.5, 23.6) | ‒2.4 (‒4.4, ‒0.4) |
| 4000 μg/wk | 25.6 (23.0, 28.8) | 1.0 (‒1.8, 4.5) |
| MTHFR 677 genotype | ||
| CC | 23.2 (21.2, 25.5) | Reference |
| CT | 25.1 (23.8, 26.6) | 1.9 (−0.7, 4.4) |
| TT | 26.3 (24.6, 28.2) | 3.1 (0.2, 5.9) |
| BMI, kg/m2 | ||
| <25 | 26.7 (25.5, 28.1) | Reference |
| 25 to <30 | 23.3 (21.9, 25.0) | −3.3 (−5.3, −1.4) |
| ≥30 | 21.9 (19.0, 26.1) | −4.5 (−8.0, −0.5) |
1
Includes data from the intervention group at baseline and 6 mo (n = 2085). CI, Bayesian credible interval; MTHFR, methylenetetrahydrofolate reductase.