Figure 1. Grip strength.
The grip strength was determined on hind- and forelimbs using a grip strength test meter at days 1, 8, 14, and 22 of the treatment period in (A) WT, (B) KO and (C) OE mice. The value at day 1 of each treatment group was set at 100%. The operator was blinded regarding the treatment of the mice. Data were normalized to body weight and are represented as mean ± SEM of 10 animals per group. *p < 0.05 between simvastatin treated and the respective control group. Abbreviations: WT, wild type; KO, PGC-1α knock-out mice; OE, PGC-1α overexpressing mice; Ctl: control; Simv, simvastatin.