Table 1. Characterization of control (Ctl) and simvastatin-treated (Simv) mice.

Mouse model	WT		KO		OE
Treatment	Ctl	Simv	Ctl	Simv	Ctl	Simv
Physiological parameter
End study body weight (g)	29.3±0.5	29.8±0.8	29.9±0.9	29.0±0.8	28.1±1.0	28.8±0.9
Daily food intake (g)	3.64±0.17	3.67±0.21	3.70±0.14	3.95±0.1	3.56±0.15	3.48±0.08
Daily water intake (mL)	4.45±0.25	4.42±0.33	4.46±0.16	4.54±0.2	4.17±0.25	4.38±0.12
	Organ weight (weight per femur length in g x mm-1)
Heart	7.82±0.48	7.46±0.52	7.21±0.44	7.12±0.21	7.42±0.45	7.48±0.21
Gastrocnemius	9.08±0.35	9.26±0.39	9.70±0.41	10.28±0.39	9.08±0.36	9.51±0.36
Soleus	0.44±0.01	0.53±0.01*	0.45±0.03	0.53±0.03	0.53±0.04#	0.51±0.05
EDL	4.11±0.21	4.32±0.14	4.17±0.24	4.36±0.26	4.26±0.06	4.28±0.33
Quadriceps	12.9±0.7	13.5±0.6	12.2±0.9	11.9±0.3	10.8±0.5#	11.5±0.5

WT wild-type mice; KO, muscle PGC-1α knockout mice; OE, muscle PGC-1α overexpression mice; EDL, extensor digitorum longus. All values are expressed as mean±SEM with n=10 per group.

^*p<0.05 between simvastatin-treated and control mice

^#p<0.05 between the control groups of KO or OE mice and WT mice.