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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Small. 2019 Mar 5;15(14):e1805526. doi: 10.1002/smll.201805526

Figure 6. Controlled drug release from the device.

Figure 6

A. Schematic representation of drug loading and release from the system. The pyrrole monomers (black spheres) are oxidized, leading to the creation of a polypyrrole film containing the negatively charged drug (blue spheres). On polypyrrole reduction, the electrostatic bonds between the polymer and the drugs are broken, leading to the release of the drug. B. Chemical reaction for polypyrrole polymerization and subsequent reduction and drug release. C. Scanning electron micrograph of a large drug release electrode with a layer of drug-loaded polypyrrole deposited on it. D. Zoomed-in image of the highlighted area in B showing a close up of the polypyrrole layer. E-G. Drug release from the device showing an on-off release profile (E- dexamethasone, F- Indomethacin, G – Aspirin). Arrows represent a period of current injection. H. Aspirin release as a function of applied current in milliampere. I. Aspirin release as a function of time with the application of a 1 mA current.