Table 2.
Comparison of the frequencies of the genetic variant rs12252 of IFITM3 among influenza infected patients and controls
| Parameter | General Spanish population (n = 246)a,b |
Patients with IVI (n = 118)c |
Patients with mild IVI (n = 58) |
Hospitalized patients with PVP (n = 60) |
Patients with ICU admission (n = 34) |
|---|---|---|---|---|---|
| HWE P value | 0.574 | 0.418 | 0.138 | 0.631 | 0.643 |
| Allele frequency, number (%) | |||||
| T | 475 (0.965) | 221 (0.936) | 108 (0.931) | 113 (0.942) | 63 (0.926) |
| C | 17 (0.0345) | 15 (0.063) | 8 (0.069) | 7 (0.058) | 5 (0.074) |
| Genotype frequency, number (%) | |||||
| TT | 229 (93.1) | 104 (88.1) | 51 (88.0) | 53 (88.3) | 29 (85.3) |
| CT | 17 (6.9) | 13 (11.0) | 6 (10.3) | 7 (11.7) | 5 (14.7) |
| CC | 0 (0.0) | 1 (0.84) | 1 (1.7) | 0 (0.0) | 0 (0.0) |
| dGeneral Spanish Population (n = 246) | |||||
| Allelic P value | … | 0.074 | 0.11 | 0.171 | 0.170 |
| Allelic OR (95 % CI) | 1.90 (0.88–4.08) | 2.07 (0.80–5.24) | 1.73 (0.63–4.56) | 2.22 (0.62–6.54) | |
| eIBS population (n = 107) | |||||
| Allelic P value | … | 0.130 | 0.13 | 0.262 | 0.169 |
| Allelic OR (95 % CI) | 2.01 (0.75–5.55) | 2.19 (070–6.92) | 1.83 (0.56–5.98) | 2.35 (0.56–8.90) | |
| fGeneral Spanish population and IBS population (n = 353) | |||||
| Allelic P value | … | 0.048 g | 0.11 | 0.149 | 0.167 |
| Allelic OR (95 % CI) | 1.93 (0.94–3.91) | 2.10 (0.85–5.08) | 1.76 (0.62–4.33) | 2.26 (0.65–6.31) | |
No significant differences were observed when genotype frequencies were compared
IFITM3 interferon-inducible transmembrane protein 3, IVI influenza virus infection, PVP primary viral pneumonia, ICU intensive care unit, HWE Hardy-Weinberg equilibrium, OR odds ratio (95 % confidence interval)
aDonors were recruited at four tertiary Spanish Hospitals
b33.28 ± 16.47 year-old; 44 % males
c45.81 ± 18.4 year-old; 57.6 % males
dComparisons included 246 Caucasian Spanish individuals from the general Spanish population of our study
eComparisons included 107 individuals from Iberian population in Spain, IBS (1000 Genomes project)
fComparisons included 353 individuals from the general Spanish population of our study together with the Iberian population in Spain, IBS (1000 Genomes project)
g P < 0.05