Table 2.
Complications and outcomes of patients undergone autologous stem cell transplant
| Patient no. | Age at AHSCT (years) | Interval between Dx and recurrence | Stem cell source | Liver toxicity (grade) | Renal toxicity (grade) | Other complications | Disease status after AHSCT | Time to recurrence or progression (months) | Outcome | LPSa |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 8.6 | 13 | PBSCb | 1 | Nil | Nil | CRc | 13 | Died at D + 493 | N/Ad |
| 2 | 14.3 | 7 | PBSC | 1 | Nil | Pulmonary TB | CR | N/A | Survives for 9.8 years | 90 |
| 3 | 5.2 | 18 | PBSC | 4 | 2 | Bacillus cereus sepsis, Cl. difficile colitis, VODe | CR | N/A | Survives for 9.4 years | 80 |
| 4 | 3.9 | 6 | PBSC | 1 | Nil | Otitis externa | SDf | 8 | Died at D + 299 | N/A |
| 5 | 6.4 | 13 | PBSC | 1 | 1 | E. coli UTIg | CR | N/A | Survives for 6.0 years | 90 |
| 6 | 6.9 | 25 | PBSC | 1 | 1 | Upper GIBh | SD | 4 | Died at D + 293 | N/A |
| 7 | 3.4 | 11 | BMi | 2 | Nil | Upper GIB | CR | N/A | Survives for 5.4 years | 80 |
| 8 | 11.7 | N/Ad | PBSC | 4 | 2 | Acute sensorineural hearing loss, subdural hematoma, Cl. difficile colitis, enterococcus UTI | CR | 11 | Died at D + 632 | N/A |
| 9 | 4.4 | 9 | BM | 2 | 1 | Pseudomonas aeruginosa UTI | CR | N/A | Survives for 5.0 years | 50 |
| 10 | 20 | 16 | PBSC | 4 | 4 | E. coli sepsis, engraftment syndrome with ARDS, pleural effusion, pneumonia, pneumothorax, GIB, acute renal failure | CR | N/A | Died at D + 46 | N/A |
| 11 | 11.2 | 14 | PBSC | 4 | 1 | Transient visual loss, VOD, seizure | CR | N/A | Survives for 1.8 years | 90 |
| 12 | 11.8 | 29 | PBSC | 3 | Nil | Norovirus GEj, pneumonia, early CMV infection | SD | 4 | Died at D + 249 | N/A |
| 13 | 2.7 | 9 | BM | 2 | Nil | Cl. difficile colitis | CR | N/A | Survives for 1.2 years | 80 |
aLPS, Lansky-Karnofsky performance score; bPBSC, Peripheral blood stem cell; cCR, Complete remission; dN/A, Not applicable; eVOD, Hepatic veno-occlusive disease; fSD, Stable disease; gUTI, Urinary tract infection; hGIB, Gastro-intestinal bleeding; iBM, Bone marrow; jGE, Gastro-enteritis