Table 3.
Therapeutic response to ECMO for patients A-D
| 1 hr prior to ECMO start | 24 hr following ECMO start | 48 hr following ECMO start | 24 hr prior to ECMO stop | 24 hr after ECMO stop | |
|---|---|---|---|---|---|
| ECMO flow (L·min−1) | - | 4.5 (4.2-5) | 4.3 (4.1-4.6) | 3 (2.9-3.1) | - |
| PaCO2 (mmHg) | 71 (52-77) | 42 (36-45) | 42 (35-52) | 40 (36-43) | 40 (34-55) |
| pH | 7.12 (7.1-7.2) | 7.40 (7.36-7.46) | 7.37 (7.32-7.44) | 7.37 (7.34-7.41) | 7.38 (7.22-7.41) |
| Sweep flow (L·min−1) | - | 5.5 (3.5-6.9) | 6.5 (3.5-8.8) | 2.8 (0.5-7.2) | - |
| Inspired FiO2 | 1.0 (1.0-1.0) | 0.70 (0.55-0.7) | 0.43 (0.4-0.56) | 0.55 (0.43-0.6) | 0.5 (0.42-0.65) |
| ECMO FiO2 | - | 1.0 (1.0-1.0) | 1.0 (1.0-1.0) | 0.61 (0.21-1.0) | - |
| PaO2 (mmHg) | 60 (56-62) | 87 (70-116) | 74 (66-99) | 70 (60-103) | 87 (74-98) |
| PaO2/FiO2 | 60 (56-62) | 149 (100-180) | 176 (120-248) | 138 (111-205) | 169 (142-194) |
| Tidal volume (mL·kg−1 PBW) | 6.3 (5.1-7.5) | 5.2 (4.2-7) | 5.2 (3.4-7) | 7.4 (5.4-7.7) | 9.4 (7.4-11.1) |
| PEEP (cm H2O) | 15 (13-21) | 10 (10-12) | 10 (10-12) | 11(10-12) | 11(10-12) |
| PIP or Pplateau (cm H2O) | 43 (35-49) | 31 (27-35) | 25 (21-29) | 22 (18-27) | 23 (22-29) |
| Cumulative fluid balance (L) | 2.9 (−2.2-11.3) | 5 (−2.3-11) | −4.5 (−12.5-7.3) | −5.7 (−15-10.2) | |
| Norepinephrine dose (µg·kg−1·min−1) | 0.33 (0.1-0.6) | 0.01 (0-0.05) | 0.02 (0-0.08) | 0 (0-0.04) | 0 (0-0.02) |
| Vasopressin dose (U·hr−1) | 2.4 (2.4-2.9) | 0.6 (0-2.1) | 0 (0-1.8) | 0 (0-1.8) | 0 (0-1.8) |
| Mean arterial pressure (mmHg) | 68 (55-70) | 75 (70-82) | 76 (67-82) | 89 (83-94) | 78 (68-80) |
| Heart rate (beats·min−1) | 138 (102-146) | 91 (81-106) | 90 (74-116) | 95 (83-115) | 114 (99-127) |
| Patients receiving continuous venovenous hemodiafiltration (n) | 0 | 1 | 3 | 2 | 2 |
| Lactate (mmol·L−1) | 3.4 (3-4) | 2.5 (2-7.4) | 2.7 (2.2-6.2) | 1.6 (1.3-2.3) | 1.5 (1.3-1.9) |
| Platelets (number ×10−9·L−1) | 355 (201-505) | 246 (145-481) | 182 (143-303) | 66 (46-271) | 88 (75-181) |
AST = aspartate aminotransferase; ECMO = extracorporeal membrane oxygenation; FiO2 = fraction of inspired oxygen; PaCO2 = partial pressure of carbon dioxide; PaO2 = partial pressure of oxygen; PBW = predicted body weight; PEEP = positive end-expiratory pressure; PIP = peak inspiratory pressure; Pplateau = plateau pressure; SvO2 = central venous oxygen saturation