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. Author manuscript; available in PMC: 2020 Mar 27.
Published in final edited form as: Cancer Res. 2018 Aug 28;78(20):5793–5807. doi: 10.1158/0008-5472.CAN-18-0195

Fig. 4. Effect of BIM silencing or BCL-2/MCL-1 expression on the apoptosis of STAT5-silenced Ph+ ALL cells.

Fig. 4.

(A, B, E) Western blots show expression of BCL-2, MCL-1 and BIM in the indicated STAT5-silenced Ph+ ALL cell lines (A) and in the shSTAT5-BV173 derivative line transduced with the Doxy-regulated shBIM lentivirus (B), or in shSTAT5-BV173 ectopically expressing MCL-1 or BCL-2 (E, left), or in the shSTAT5-shBIM-BV173 line expressing MCL-1 or BCL-2 (E, right); (C, D) % of apoptotic cells detected by Annexin V staining in shSTAT5-BV173 parental and derivative cell lines, untreated or Doxy treated to silence STAT5 expression.