Table III.
Correlation of nephropathy-related parameters with markers of nitric oxide metabolism.
| Groups | Variable 1 | Variable 2 | Correlation coefficient (R) | P-value |
|---|---|---|---|---|
| Healthy subjects | eGFR | NO2-+NO3- urine | 0.688 | 0.008 |
| Type 1 diabetes | eGFR | NO2-+NO3- urine | 0.190 | 0.002 |
| Healthy subjects | eGFR | NO2-+NO3- serum | 0.090 | 0.762 |
| Type 1 diabetes | eGFR | NO2-+NO3- serum | -0.051 | 0.406 |
| Healthy subjects | eGFR | NO | -0.215 | 0.222 |
| Type 1 diabetes | eGFR | NO | -0.099 | 0.165 |
| Type 1 diabetes | Diabetes duration | NO2-+NO3- urine | -0.131 | 0.032 |
| Type 1 diabetes | Diabetes duration | NO2-+NO3- serum | 0.049 | 0.425 |
| Type 1 diabetes | Diabetes duration | NO | -0.029 | 0.684 |
| Type 1 diabetes | Albuminuria | NO2-+NO3- urine | -0.064 | 0.304 |
| Type 1 diabetes | Albuminuria | NO2-+NO3- serum | 0.150 | 0.015 |
| Type 1 diabetes | Albuminuria | NO | 0.094 | 0.184 |
| Healthy subjects | NO2-+NO3- urine | NO2-+NO3- serum | 0.492 | 0.002 |
| Type 1 diabetes + no DN | NO2-+NO3- urine | NO2-+NO3- serum | 0.559 | <0.001 |
| Type 1 diabetes + DN | NO2-+NO3- urine | NO2-+NO3- serum | 0.351 | 0.120 |
| Healthy subjects | NO | NO2-+NO3- serum | -0.253 | 0.120 |
| Type 1 diabetes + no DN | NO | NO2-+NO3- serum | -0.095 | 0.200 |
| Type 1 diabetes + DN | NO | NO2-+NO3- serum | -0.339 | 0.216 |
| Healthy subjects | NO | NO2-+NO3- urine | -0.216 | 0.188 |
| Type 1 diabetes + no DN | NO | NO2-+NO3- urine | -0.042 | 0.570 |
| Type 1 diabetes + DN | NO | NO2-+NO3- urine | -0.332 | 0.246 |
R-Spearman correlation coefficient. eGFR, estimated glomerular filtration rate; DN, diabetic nephropathy; albuminuria, albumin/creatinine ratio in morning spot urine; NO, nitric oxide; NO2, nitrite; NO3, nitrate.