Table II.
Genotype and allele distributions of miR-155 rs767649 A>T and miR-146a rs57095329 A>G in MS cases and control group.
| A, miR-155 rs767649 (A>T) | ||||
|---|---|---|---|---|
| Genotypes and Alleles | MS cases, n (%) | Controls, n (%) | Unadjusted P-value, OR (95% CI) | Adjusted P-value, OR (95 % CI)a |
| TT | 39 (34.2) | 16 (10.5) | <0.001, 8.125 (3.408-19.370) | <0.001, 8.600 (3.556-20.800) |
| AT | 63 (55.3) | 96 (63.2) | 0.033, 2.187 (1.066-4.490) | 0.026, 2.317 (1.104-4.864) |
| AA | 12 (10.5) | 40 (26.3) | 1 | |
| Dominant model | ||||
| TT+AT | 102 (89.5) | 112 (73.7) | 0.002, 3.036 (1.510-6.105) | 0.001, 3.282 (1.599-6.738) |
| AA | 12 (10.5) | 40 (26.3) | 1 | |
| Recessive model | ||||
| TT | 39 (34.2) | 16 (10.5) | <0.001, 4.420 (2.315-8.438) | <0.001, 4.479 (2.341-8.571) |
| AA+AT | 75 (65.8) | 136 (89.5) | 1 | |
| Allele T | 141 (61.8) | 128 (42.1) | <0.001, 2.228 (1.569-3.166) | <0.001, 2.260 (1.588-3.218) |
| Allele A | 87 (38.2) | 176 (57.9) | 1 | |
| B, miR-146a rs57095329 (A>G) | ||||
| Genotypes and Alleles | MS cases n (%) | Controls n (%) | Unadjusted P-value OR (95% CI) | Adjusted P-value OR (95 % CI)a |
| GG | 3 (2.6) | 16 (10.5) | 0.003, 0.148 (0.041-0.531) | 0.004, 0.149 (0.041-0.539) |
| AG | 30 (26.3) | 72 (47.4) | <0.001,0.329(0.192-0.564) | <0.001, 0.323 (0.187-0.556) |
| AA | 81 (71.1) | 64 (42.1) | 1 | |
| Dominant model | ||||
| GG+AG | 33 (28.9) | 88 (57.9) | <0.001, 0.296 (0.177-0.497) | <0.001, 0.291 (0.173-0.492) |
| AA | 81 (71.1) | 64 (42.1) | 1 | |
| Recessive model | ||||
| GG | 3 (2.6) | 16 (10.5) | 0.022, 0.230 (0.065-0.809) | 0.024, 0.233 (0.066-0.827) |
| AA+AG | 111 (97.4) | 136 (89.5) | 1 | |
| Allele G | 36 (15.8) | 104 (34.2) | <0.001, 0.361 (0.235-0.553) | <0.001, 0.361 (0.235-0.555) |
| Allele A | 192 (84.2) | 200 (65.8) | 1 | |
aAdjusted by age and sex. CI, confidence interval; OR, odds ratio; MS, multiple sclerosis; miR, microRNA.