Table 1.

Non-exhaustive list of recombinant proteins produced in plants, with the pathology and clinical status phases indicated for each recombinant protein

Recombinant protein	Class	Plant	Pathology	Clinical trial status	Reference or company website
CaroRX™	Antibody	Tobacco	Tooth decay	Approved as medical device	http://www.planetbiotechnology.com/
DoxoRX™	Antibody	Tobacco	Side effects of cancer therapy	Phase I complete	http://www.planetbiotechnology.com/
RhinoRX™		Tobacco	Rhinovirus prophylactic	Phase II	http://www.planetbiotechnology.com/
Fv antibodies (38C13)	Antibody	Tobacco	Lymphoma	Phase I complete	http://www.lsbc.coma
IgG (ICAM1)	Antibody	Tobacco	Common cold	Phase I	http://www.planetbiotechnology.com/
Antibody hepatitis B	Antibody	Tobacco	Hepatitis B	On market	[115]
2 G12IgG1	Antibody	Maize	HIV-1	Phase I	http://www.pharma-planta.net/
		Tobacco
Antitumor necrosis factor (Pr-anti-TNF)	Antibody	Carrot	Arthritis	Preclinical	http://www.protalix.com/
Anti-CD20 mAb (BLX-301)	Antibody	Duckweed	Lymphomas	Preclinical	http://www.biolex.com/
MAPP66	Antibody	Tobacco	HSV/HIV microbicide	Phase I	http://www.bayer.com/
Avicidin®	Antibody	Maize	Colorectal cancer	Withdraw from phase II
IgA (HIgA-1)	Antibody	Soybean	HSV	Phase I	http://www.epicyte.com/
Cholera toxin B subunit (CTB)	Vaccine	Rice	Cholera	Phase I	[116, 117]
LT-B	Vaccine	Maize	Diarrhea	Phase I	[118]
		Potato		Phase I
LT-B and TGEV glycoprotein S	Vaccine	Maize	Diarrhea and gastroenteritis	Phase I	[119]
HBsAg	Vaccine	Lettuce	Hepatitis	Phase I	[120]
		Potato			[121]
HBsAg-env, gag epitopes of HIV-1	Vaccine	Tomato	Hepatitis		[122]
Norwalk virus capsid protein (NVCP)	Vaccine	Potato	Gastroenteritis	Phase I	[123]
Major capsid protein VP6	Vaccine	Potato	Severe viral diarrhea	Preclinical	[124]

HBsAg hepatitis B surface antigen, HSV herpes simplex virus, ICAM intercellular adhesion molecule, LT-B heat labile enterotoxin B subunit, mAb monoclonal antibody, TGEV transmissible gastroenteritis virus