Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2006 Oct 30;25(51):6844–6867. doi: 10.1038/sj.onc.1209941

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Nature Publishing Group 2006

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

PMC Copyright notice

Viruses inhibit distinct aspects of the antiviral response. Influenza virus NS1 protein, as well as Vaccinia E3L prevents viral dsRNA from being recognized. The V proteins of paramyxoviruses, including SV5, Mumps and Hendra viruses, bind to Mda-5 and block downstream signaling. Ebola virus VP35 bids to RIG-I and blocks downstream signaling. RSV and RV interfere with activation of IRF-3 in virus-infected cells. The RV P protein inhibits TBK-1-mediated phosphorylation of IRF-3. VSV M protein blocks nuclear to cytoplasmic export of IFN and cellular mRNA (modified from Conzelmann, 2005). HCV core protein and ASFV block NF-κB activation. Measles virus and RSV block IFNα and IFNβ production.