Table 2.
Pharmacology/Molecular Summary: Relationship to EE and/or Sucrose-Directed Behaviors (operant)
| Citation | Manipulation/Technique | Effects |
|---|---|---|
| Grimm et al., (2016) | Overnight (acute) or 29 day (chronic) EE as intervention post-training cFos immunohistochemistry immediately after sucrose seeking test |
(selected results) Prelimbic cortex: acute or chronic EE ↓ cFos Infralimbic cortex: acute EE ↑ cFos Orbitofrontal cortex: acute or chronic EE ↓ cFos Nucleus Accumbens Core: late abstinence acute or chronic EE ↓ cFos Nucleus Accumbens Shell: late abstinence acute or chronic EE ↓ cFos Dorsolateral Striatum: acute or chronic EE ↓ cFos |
| Slaker et al., (2016) | Overnight (acute) or 29 day (chronic) EE as intervention post-training Wisteria agglutinin immunohistochemistry; intensity of immunoreactivity |
Immediately after acute EE (no sucrose history): Prelimbic cortex: ↓ PNN intensity Infralimbic cortex: no change Orbitofrontal cortex: ↑ PNN intensity Or Immediately after sucrose-seeking test; acute or chronic EE (Figure 9): Prelimbic cortex: acute or chronic EE ↑ PNN intensity Infralimbic cortex: acute EE ↑ PNN intensity Orbitofrontal cortex: acute or chronic EE ↑ PNN intensity |
| Glueck et al., (2017) | Overnight (acute) or 29 day (chronic) EE as intervention post-training Dopamine D1 or D2 agonist administered after EE but prior to sucrose seeking |
D1 agonist (SKF81297) reversed EE anti-seeking effect at both early and late abstinence; D2 agonist (quinpirole) reversed EE anti-seeking effect only at early abstinence |
| Grimm et al., (2018) | Overnight (acute) or 29 day (chronic) EE as intervention post-training DARPP32 and DARPP32 pThr34 immunoreactivity using Western blot following sucrose seeking or no test control |
(selected results of changes in pThr34) Prelimbic cortex: no change Infralimbic cortex: chronic EE ↑ Orbitofrontal cortex: chronic EE ↓, acute EE early abstinence ↑ (trend), acute EE late abstinence ↓ (trend) Nucleus accumbens core: acute EE ↑ Nucleus accumbens shell: no change Dorsolateral striatum: no change |
Note. All studies used adult, male rats.