Table 1.
Major viral vaccines commercially available in India
| Disease | Vaccine name | Manufacturer | Description/composition | Presentation | Dosage/schedule |
|---|---|---|---|---|---|
| Rotavirus diarrhea | RotaTeq® | Merck Sharp & Dohme (MSD) | Live pentavalent human-bovine reassortant rotavirus vaccine containing G1, G2, G3, G4 and P1A[8] viruses | Ready-to-use 2 ml solution | To be administered orally in a 3-dose regimen |
| Rotarix® | GlaxoSmithKline (GSK) | Live-attenuated monovalent human rotavirus vaccine containing G1P[8] virus | Lyophilized vaccine. 1 ml dose + diluent | To be administered orally in a 2-dose regimen | |
| Rabies | RABIVAX® | Serum Institute of India Ltd. | Rabies virus (Pitman-Moore strain) propagated on human diploid cells; β-propiolactone (BPL) inactivated | 1 ml vials/ampoules (single/multiple dose packs) | Pre-exposure: 3 doses by intra-muscular (i.m.) route. 1st booster after 1 year; subsequent boosters every 5 years. |
| Post-exposure: 5 doses by i.m. route. Booster on day 90 (optional) | |||||
| Abhayrab™ | Indian Immunologicals Ltd. | Rabies virus (L. Pasteur 2061/Vero) propagated on Vero cell line; BPL-inactivated | Freeze-dried vaccine. Single dose vial + diluent | As above | |
| INDIRAB™ | Bharat Biotech International Ltd. | Rabies virus (Pitman-Moore strain) propagated on Vero cells; BPL- inactivated. | Lyophilized vaccine. Single dose vial + diluent + disposable syringe with needle | As above | |
| VaxiRab™ | Zydus Cadila | Purified duck embryo vaccine | Lyophilized vaccine. Single dose vial + diluent | As above | |
| Hepatitis B | Gene Vac-B® | Serum Institute of India Ltd. | HBsAg expressed in Hansenula polymorpha (Pichia angusta) | Pediatric/adult dose packs (single/10 doses) | Adults: 3 doses (20 μg HBsAg in each) by i.m. route. |
| Neonates, children and adolescents up to 19 years: 3 doses (10 μg HBsAg in each) by i.m. route | |||||
| Enivac HB™ | Panacea Biotec Ltd. | HBsAg expressed in Pichia pastoris | Multi-vial dose. Pack of 1 vial of 100 μg/5 ml | As above | |
| Enivac HB™ Safsy | Panacea Biotec Ltd. | As above | Uniject Safsy. Pre-filled ready- to-use device (single adult dose) | As above | |
| Elovac-B® | Indian Immunologicals Ltd. | As above | Single/multiple dose packs | As above | |
| Revac-B+™ | Bharat Biotech International Ltd. | As above | Pediatric/adult dose packs (single/10 doses) | As above | |
| Revac-Bmcf | Bharat Biotech International Ltd. | As above (Thiomersal-free) | Pediatric/adult single dose packs | As above | |
| Cervical cancer | Gardasil® | Merck Sharp & Dohme (MSD) | Quadrivalent HPV (6, 11, 16, 18) VLP-based vaccine using L1 protein of HPV expressed in S. cerevisiae | Single dose vials/pre-filled syringes | 3 doses on 0, 2, 6 months by i.m. route |
| Cervarix® | GlaxoSmithKline (GSK) | Bivalent HPV (16, 18) VLP-based vaccine using L1 protein of HPV expressed in baculovirus | Single dose vials/pre-filled Tip-Lok syringes | 3 doses on 0, 1, 6 months by i.m. route | |
| Measles | M-VAC™ | Serum Institute of India Ltd. | Live-attenuated measles virus (Edmonston Zagreb strain) propagated on human diploid cells (HDC) | Lyophilized vaccine. Single dose vial + sterile water for injection | Single dose by subcutaneous (s.c.) route |
| Rubella | R-VAC™ | Serum Institute of India Ltd. | Live-attenuated Wistar RA 27/3 strain rubella virus propagated on HDC | Lyophilized vaccine. Single/multiple dose packs | As above |
| Measles and Rubella | Measles and Rubella Vaccine Live U.S.P. | Serum Institute of India Ltd. | Live-attenuated strains of Edmonston-Zagreb measles virus and Wistar RA 27/3 rubella virus, both propagated on HDC | Freeze-dried vaccine. 1, 2, 5, 10 dose vial + diluent | As above |
| Measles, Mumps and Rubella (MMR) | TRESIVAC™ | Serum Institute of India Ltd. | Live attenuated strains of Edmonston-Zagreb measles virus propagated on HDC, L-Zagreb mumps virus propagated on chick embryo fibroblast cells (CEFC) and Wistar RA 27/3 rubella virus propagated on HDC | Lyophilized vaccine. Single/multiple dose packs | As above |
| Abhay-Vac 3 | Indian Immunologicals Ltd. | As above | 50 vials with 5 doses of vaccine in a box and 50 ampoules with 2.5 ml of water for injection in a box | As above | |
| Pandemic (H1N1) Influenza | NASOVAC™ | Serum Institute of India Ltd. | Live-attenuated pandemic influenza (H1N1) virus propagated in specific pathogen free (SPF) embryonated hen eggs | Freeze-dried vaccine. Single and 5 dose vial + diluent | 0.5 ml intranasal spray (0.25 ml per nostril) |
| Polio | Monovalent oral polio vaccine (mOPV) Type 1 | Panacea Biotec Ltd. | Live-attenuated poliomyelitis type 1 virus (Sabin strain) propagated in monkey kidney cells or Vero cells | Multi-dose vials of 20 doses | To be administered orally |
| mOPV Type 3 | Panacea Biotec Ltd. | Live-attenuated poliomyelitis type 3 virus (Sabin strain) propagated in monkey kidney cells | As above | As above | |
| OPV | Panacea Biotec Ltd. | Live-attenuated poliomyelitis types 1, 2 and 3 viruses (Sabin strains) propagated in monkey kidney cells | As above | As above | |
| BIOPOLIO™ | Bharat Biotech International Ltd. | As above | As above | As above |