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. 2020 Mar 20;14:60. doi: 10.3389/fncel.2020.00060

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Copyright © 2020 Korshunov, Blakemore, Bertram and Trombley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the effects of ramp slopes on the spike frequencies and the number of spikes of OB DA neurons. (A) The frequency responses (in Hz) of neurons (n = 13) that spiked more than once per ramp stimulus increase with increasing ramp slopes. (B) After transforming these power functions into log-log plots (see section “Materials and Methods”), there was no difference (n = 13, p = 0.3544) in the increasing spike frequencies with increasing ramp slopes between Top and Bottom DA neurons. (C) The increasing spike frequencies with increasing ramp slopes was significantly higher (n = 7, p < 0.0043**) in Small than Large neurons. (D) Number of spikes produced with increasing ramp slopes of neurons (n = 13) drops dramatically, particularly between 0 and 2 pA/ms ramps. (E) Top DA neurons produced a significantly greater decrease in spikes across increasing ramp slopes than did Bottom neurons (n = 13, p = 0.0009***). (F) There was an even greater decrease in spikes across increasing ramp slopes in Large compared to Small DA neurons (n = 7, p < 0.0001****).