. 2019 Jun 19;7(3):83–90. doi: 10.1007/s40138-019-00188-z

Table 2.

Empiric antibiotic recommendations from the Canadian Pediatric Society and the American Academy of Pediatrics

	Canada	AAP
RF	- Intrapartum GBS colonization - GBS bacteriuria during the current pregnancy - Previous infant with invasive GBS disease - PROM ≥ 18 h - Maternal fever (temperature ≥ 38 °C)	- GBS colonization without abx - PROM ≥ 18 h - Chorioamnionitis
Labs	Infants should be investigated and treated using an individualized approach that includes consideration of the severity of risk factors and maternal abx therapy. At minimum, infants should have close observation in hospital for at least 24 h with vital signs every 3 to 4 h and reassessment before discharge. A CBC done after 4 h of age may be helpful; WBC < 5 × 10⁹/L and ANC < 1.5 × 10⁹/L have the highest positive predictive value. Some infants may warrant investigation and antibiotic therapy. (Weak recommendation, low quality evidence.)	- WBC/diff ± CRP at 6–12 h

Canada

AAP

- Intrapartum GBS colonization

- GBS bacteriuria during the current pregnancy

- Previous infant with invasive GBS disease

- PROM ≥ 18 h

- Maternal fever (temperature ≥ 38 °C)

- GBS colonization without abx

- PROM ≥ 18 h

- Chorioamnionitis

Labs

Infants should be investigated and treated using an individualized approach that includes consideration of the severity of risk factors and maternal abx therapy.

At minimum, infants should have close observation in hospital for at least 24 h with vital signs every 3 to 4 h and reassessment before discharge.

A CBC done after 4 h of age may be helpful; WBC < 5 × 10⁹/L and ANC < 1.5 × 10⁹/L have the highest positive predictive value. Some infants may warrant investigation and antibiotic therapy. (Weak recommendation, low quality evidence.)

- WBC/diff ± CRP at 6–12 h