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ARC520. a A co-administered modified cholesterol-conjugated siRNA and b NAG-MLP polymer. c Both components are endocytosed by the respective receptors. In the acidic endosome, NAG is released and MLP is able to associate and disrupt the endosome membrane. This allows siRNA to be released into the cytoplasm, where it can associate with RISC, leading to HBV RNA degradation
