Skip to main content
. 2017 Mar 21;375(2):38. doi: 10.1007/s41061-017-0127-6

Fig. 8.

Fig. 8

Obstacles to the uptake of naked siRNA. a Degradation of siRNA by nucleases in the serum; b clearance through the liver and kidney by the reticuloendothelial system; c poor tissue permeability; d poor cell uptake due to negative charge on cell membrane and siRNA; e inefficient release from the endosome