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. Author manuscript; available in PMC: 2020 Jul 15.
Published in final edited form as: Nature. 2020 Jan 15;577(7792):689–694. doi: 10.1038/s41586-019-1912-x

Figure 2. Human GBM is deprived of lymphangiogenic signals at steady state but increases after αPD-1 therapy.

Figure 2

RNAseq data of tumor tissue (TCGA, phs000178.v10.p8) and healthy brain cortex (GTEX, phs000424.v7.p2). a-c Expression profiles of VEGF-A, CD31 (angiogenic) and VEGF-C (lymphangiogenic) genes in cortex versus GBM samples (cortex, n = 133; GBM, n = 147, patient samples). d-f RNAseq correlation of change in VEGF-C and T cell markers after PD-1 therapy (data from GSE121810, n = 24). Data are mean ± S.D. *P < 0.05; **P < 0.01; ***P <0.001; ****P<0.0001 (two-tailed unpaired Student’s t-test, Pearson’s correlation)