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Change in hot flash frequency stratified by APOE genotype. 4A, APOE3/3 participants on PS50 showed significant reduction in hot flash frequency. 4B, APOE3/4 participants on PS50 showed non-significant decline in hot flash frequency relative to the placebo group. PS50, PhytoSERM 50gm/day; PS100, PhytoSERM 100mg/day. * p<0.05.
