Change in participants’ RAVLT Learning Over Trial score (verbal learning ability) stratified by mitochondrial haplogroup. 5A, haplogroup H participants on placebo displayed significantly more decline in verbal learning ability compared to their non-haplogroup H counterparts. 5B, in haplogroup H participants, treatment with 50mg of daily PhytoSERM preserved verbal learning ability in comparison to those on placebo. 5C, no difference was observed among three treatment groups in non-haplogroup H participants. PS50, PhytoSERM 50gm/day; PS100, PhytoSERM 100mg/day. * P<0.05.