Extended Data Figure 9: Membrane context and curvature for NTSR1-βarr1^ΔCT.

a) Comparison of NTSR1-βarr1^ΔCT and NTSR1-cGi structures, for which membrane-embedded regions were computed using the Orientations of Proteins in Membranes server (https://opm.phar.umich.edu/). The membrane is indicated by grey spheres to show the extent to which the C-edge would insert into the membrane. b) The extent of arrestin tilt observed in the NTSR1-βarr1^ΔCT structure could also be relevant to the increased membrane curvature observed in endocytic vesicles. As an example, several membrane bilayers are drawn (in red) to scale, comparing the degree of curvature for vesicles ranging from 120 nm to 50 nm in diameter relative to a planar bilayer.