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. Author manuscript; available in PMC: 2020 Aug 17.
Published in final edited form as: Nat Struct Mol Biol. 2020 Feb 17;27(3):233–239. doi: 10.1038/s41594-020-0379-7

Extended Data Fig. 4. Nucleotide-induced conformational changes in SMC ATPases.

Extended Data Fig. 4

a, Structural alignment based on ATPγS-bound CtSMC1, the nucleotide-free form of Bacillus subtilis (Bs) SMC and the ATPγS-bound form of Geobacillus stearothermophilus (Gs) SMC. b, Nucleotide free (grey) and bound (green) Pyrococccus furiosis (Pf) Rad50 conformations. Nucleotide binding induces an ~35° C-lobe rotation. c, Nucleotide free (teal) form of Chaetomium thermophilium (Ct) Smc2 and ATPγS-bound form of CtSmc1 (red). d, Nucleotide free (blue) form of CtSmc4 and ATPγS-bound form of CtSmc1 (red). All structural superpositions were done using the SMC N-lobe.