Fig. 1.

Normalised relative abundance of lipids identified as candidate biomarkers in the circulation of obese pregnant women at ~17 weeks gestation using p-values adjusted according to age, BMI, ethnicity, diagnosis of pre-eclampsia and parity. Candidate biomarkers that are more abundant than in controls are marked as Increased (shown in black). Eventual intervention arm (assigned randomly after the samples used in this study were collected) and sex of infant were not strongly associate with any of the variables tested. The Bonferroni corrected p-value threshold was 0·0021, based on 565 independent variables. The control group, against which the values shown were normalised, were an obese but otherwise typically healthy group (meta-data in Table 1).