Table 3.
Sensitivity analysis of the significance of candidate biomarker across each confounding factor (adjusted together). Only p-values that pass at the Bonferroni-corrected threshold (0.0021, red) or at 0.05 (green) are shown, except for sex of infant and intervention arm, where the lowest p-value is shown. HbA1C was included in the sensitivity analysis in order to identify which variables were associated with measured hyperglycaemia
| HbA1C | Maternal BMI | Maternal Age | parity (0-7) | parity code* | Ethnicity (all) | Ethnicity (Black) | Ethnicity (White) | Ethnicity (Asian) | Diagnosis of PET | Sex if infant | Int. arm | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CE(18:3) | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| CE(20:5)a | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |||||||
| Iyso-PC(15:0) a | 0.04 | 0.00 | 0.04 | 0.00 | ||||||||
| Iyso-PC(16:0) | 0.00 | 0.01 | ||||||||||
| Iyso-PC(18:1) | 0.00 | 0.01 | 0.00 | 0.02 | 0.02 | |||||||
| PC(36:5) a | 0.01 | 0.00 | 0.00 | 0.00 | ||||||||
| PC(38:5) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |||||||
| PC(40:10) | 0.03 | |||||||||||
| PC(40:07) | 0.01 | 0.03 | 0.01 | 0.02 | ||||||||
| PC-O(18:1) a | 0.03 | 0.04 | 0.00 | 0.03 | 0.00 | |||||||
| PC-O(34:1) a | 0.01 | 0.00 | 0.00 | |||||||||
| PC-O(40:4) | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.04 | |||||
| PE(38:2) & PC(35:2) | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |||||
| PI(36:1) a | 0.00 | 0.00 | ||||||||||
| SM(32:1) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | |||||
| SM(41:2) | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| SM(42:3) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| DG(32:0) | 0.00 | 0.00 | 0.05 | |||||||||
| DG(34:3) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| DG(38:5) | 0.00 | 0.01 | 0.00 | |||||||||
| DG(38:6) a | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |||||||
| TG(46:5) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | |||||
| TG(48:0) | 0.00 | 0.04 | ||||||||||
| TG(48:6) | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | |||||
| TG(50:1) | 0.00 | 0.00 | ||||||||||
| TG(50:2) | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||
| TG(51:5) | 0.03 | 0.14 | ||||||||||
| TG(53:4) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |||||||
| TGox(48:2) | 0.05 | |||||||||||
| TGox(54:4) | 0.04 | 0.04 | ||||||||||
| TGox(54:7) | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| TGox(56:4) | ||||||||||||
| TGox(58:5) a | 0.04 | 0.03 | 0.00 | 0.00 | ||||||||
| TGox(58:6) | 0.01 | |||||||||||
| No. (p<0.05) | 13 | 11 | 10 | 25 | 21 | 14 | 14 | 15 | 15 | 3 | 0 | 0 |
| No. (p <0.0021) | 6 | 3 | 6 | 22 | 14 | 11 | 13 | 14 | 13 | 0 | 0 | 0 |
a
Parity was also grouped into nulli- and mono-parous participants, and multiparous ones. Int. arm, Intervention arm.
b
Unadjusted analysis only.