Fig 5. Percent change T1Gd radius vs cycles of TMZ and pre-adjuvant D/rho by MGMT methylation status.

Methylated patients (n = 9) have a clear negative trend between cycles of TMZ and volumetric response, while unmethylated patients (n = 14) show a similar trend, but with more deviance. Methylated patients have more diffuse tumors (higher pre-adjuvant D/rho) than unmethylated. Note that these trends are only observations, as this comparison lacks statistical power due to small sample size.