Figure 1.

Anchoring proteins in the regulation of Aurora kinase localization.

(a): AURKA localizes to the centrosomes in a Bora-dependent manner, where Bora acts to facilitate AURKA-dependent activation of PLK1. As M phase progresses, activated PLK1 phosphorylates Bora to promote Bora proteolysis, and AURKA associates with TPX2 to facilitate its localization to the spindle microtubules. TPX2 serves as an allosteric activator of AURKA. (b): AURKB forms the so-called Chromosome Passenger Complex (CPC), composed of AURKB and three associated non-enzymatic proteins termed INCENP, Survivin and Borealin. Following Histone H3 phosphorylation at Thr3 by the Ser/Thr kinase Haspin, Survivin mediates recruitment of the CPC to chromatin. At anaphase, Histone H3 is dephosphorylated and the CPC relocalizes to the central spindle, through binding the kinesin-6 microtubule-binding protein MKLP2. Created with BioRender.com.