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. 2020 Mar 12;16(3):e1008323. doi: 10.1371/journal.ppat.1008323

Fig 3. Allosteric myosin motor domain binding sites.

Fig 3

Allosteric modulators of myosin motor domains overlaid onto the structure of FgMyoI. Switch 2 is shown in pink. Myosin inhibitors: Pentachloropseudilin (PDB 2XEL [18]), pentabromopseudilin (PDB 2JHR [24]), blebbistatin (PDB 1YV3 [37]), tribromodichlorpseudilin (PDB 2XO8 [38]), ammosamide 272 (PDB 4AE3); positive cardiac inotrope: omecamtiv mecarbil (PDB 4PA0 [39]). The insert illustrates the steric clash between Switch 2 Y409 and blebbistatin.